Beyond sports-doping headlines: the science of laboratory tests for performance-enhancing drugs

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Pediatr Clin North Am. 2007 Aug;54(4):713-33, xi
Hatton CK
UCLA Olympic Laboratory, University of California at Los Angeles, 2122 Granville Avenue, Los Angeles, CA 90025, USA

This primer on urine analysis in sports-doping control is an overview with an emphasis on the main analytical chemistry technologies in use: gas chromatography-mass spectrometry (GC-MS), liquid chromatography-tandem mass spectrometry (LC-MS-MS), isotope ratio mass spectrometry detection of exogenous testosterone use, and isoelectric focusing detection of recombinant erythropoietin (EPO) use. Included are graphic examples of GC-MS selected ion monitoring and full scan, LC-MS-MS, and EPO test electropherogram data; a list of common acronyms; and answers to questions frequently asked about tampering and test accuracy.

DJ note: Make sure one can not rule out that the science behind isoelectric focusing detection of recombinant erythropoietin by this and other labs is faked. Learn more

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