Current role of LC-MS(/MS) in doping control
Anal Bioanal Chem. 2007 Aug;388(7):1351-8. Epub 2007 Jan 30.
Thevis M, Schanzer W.
Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany
PubMed ID & Record: 17265083
Liquid chromatography-(tandem) mass spectrometry (LC-MS/MS) has revolutionized the detection assays used in doping control analysis over the last decade. New methods have enabled the determination of drugs that were formerly difficult to detect or undetectable at preceding sample concentrations, and complex and/or time-consuming procedures based on alternative chromatographic-mass spectrometric or immunochemical principles have been replaced by faster, more comprehensive and robust assays. A critical overview of the contributions of LC-MS(/MS) to sports drug testing is provided, including recent developments regarding low and high molecular weight drugs.
Thevis M, Schanzer W.
Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany
PubMed ID & Record: 17265083
Liquid chromatography-(tandem) mass spectrometry (LC-MS/MS) has revolutionized the detection assays used in doping control analysis over the last decade. New methods have enabled the determination of drugs that were formerly difficult to detect or undetectable at preceding sample concentrations, and complex and/or time-consuming procedures based on alternative chromatographic-mass spectrometric or immunochemical principles have been replaced by faster, more comprehensive and robust assays. A critical overview of the contributions of LC-MS(/MS) to sports drug testing is provided, including recent developments regarding low and high molecular weight drugs.
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